We have read a lot of news about the investigations that are being carried out to find a male contraceptive pill (and time waiting). However, none has yet managed to go from the experimental phase to being commercialized. We remember that trial of a contraceptive injection that was proving to be very effective but had side effects very similar to those of the female pillalso showing promising results Dmau or ENDO 2019, which has successfully passed safety tests and works by reducing sperm production without affecting libido.
However, the latest news reaching us from New York suggests that the winning formula could not go through the hormonal. And it is that, a study carried out by a team from the Weill Cornell Medicine College (in the United States) has discovered that soluble inhibitors of the sAC enzyme (essential for sperm to mature and swim) can reduce the ability to move that sperm have. spermatozoa in mice and humans in response to certain stimuli.
This finding, which has just been published Nature Communications, could be translated into a pill that men would take before sexual activity and regain fertility the next day. And it is that the team has developed a compound called TDI-11816, which inactivates the enzyme.
100% contraceptive efficacy
Once injected into mice, this compound has been shown to cause rodents to produce sperm unable to propel themselves forward, thus preventing their maturation. In addition, it has not interfered with the sexual behavior of animals while fertility it was suppressed during the hours following drug administration.
Another positive aspect is that the study indicates that were not observed Negative effects to health during continued administration of these drugs for six weeks. In addition, with a single dose it was possible to immobilize the spermatozoa of mice for two and a half hours, having a contraceptive efficacy of 100%.
Although, after three hours some of them were already beginning to recover, losing 9% of that effectiveness. Sperm return to normal within 24 hours. yes, still we have to continue investigating to find out if this drug works effectively in humans and to be able to identify possible side effects.
Cover photo | Vidar Nordli-Mathisen